Project Details

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Professor Paul Morgan

Contact Supervisor

Project area or title

Measuring and mapping cognitive decline following brain radiotherapy


Radiotherapy is used to treat both primary brain cancer and brain metastases. Chemo-radiotherapy alters brain structures by size and function. However, depending on the tumour location, the regions of the brain given the highest radiation dose will vary. By overlaying the radiation doses on patients’ MRI scans, high and low dose regions can be mapped, and an analysis technique call VBM correlates them with specific cognitive changes.

This project will identify a suitable patient population undergoing radiotherapy, acquire cognitive status information, and undertake VBM to identify the regions linked to cognitive decline. This will inform future international radiotherapy planning guidelines.


Physical Health and Mental Health Multimorbidity


University of Nottingham