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Assistant Professor Claudia Danielmeier

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Dynamic neurometabolite changes as a new marker for cognitive impairment in early psychosis


Cognitive impairments in psychosis are one of the best predictors of quality of life and day-to-day functioning. Unfortunately, there are no cognitive treatments that are effective for all individuals. To personalise cognitive treatments in the future, we aim to establish a new neurocognitive marker based on changes in glutamate levels in the brain during cognitive tasks. We will then evaluate its potential to predict the efficacy of cognitive interventions. We will use transcranial direct current stimulation (tDCS) to improve cognitive performance as tDCS modulates glutamatergic neurotransmission. We will also conduct interviews with lived-experience-experts to increase acceptability of new interventions.


Severe Mental Health


University of Nottingham