Project Details

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Dr Jack Rogers

Project area or title

Clinical High-Risk Immune and Neurobiological Dysfunction (CHIMED)


Immune dysfunction may be causally linked to psychiatric disorders, particularly in young people at clinical high-risk (CHR) for transition to psychosis, with alterations of immune protein levels (interleukin-6; IL-6) and oxidative stress markers (glutathione) reported in patients with psychotic disorders. This project will explore whether mediators of innate immune response are associated with changes in brain-related neurobiological mechanistic processes in CHR individuals. Complementary data will investigate whether IL-6 and related cytokines impact on the neurophysiological processes that underpin fundamental cognitive functions. Multivariate approaches will help validate clinical and neurobiological markers of CHR transition to psychosis.


Severe Mental Health


University of Birmingham