Project area or title
Studying cerebral control of gait in Mild Cognitive Impairment (MCI)
Gait abnormalities is a predictor of developing dementia and dual task gait help detect MCI patients with high risk to develop dementia. Some patients with Alzheimer’s disease (AD) present with early gait difficulties. Currently, patients with mild cognitive impairment need to have invasive lumbar puncture, seeking traces of neurodegeneration and/or radioactive positron emission tomography imaging, to identify whether they are likely to develop AD. Using OPM-MEG, brain activation and connectivity can be studied while walking. We would like to study brain activation while walking, as an early predictor of progressive neurodegeneration at our deeply phenotyped group of patients with MCI.
University of Nottingham