Project area or title
Discovering blood-based RNA biomarkers for improving clinical diagnosis of Dementia with Lewy bodies
There is an urgent clinical need for identifying blood-based biomarkers that can accurately differentiate between the two most common dementias, Alzheimer’s disease (AD) and Dementia with Lewy Bodies (DLB).
Plasma, platelets, and small extracellular vesicles (SEV) carry RNA that reflect molecular changes in brain. Differentially expressed RNA including microRNAs from DLB and AD participants (n=30/group) will be identified using next-generation RNA-sequencing from Platelet-rich-plasma, Platelet-free-plasma, and plasma SEV. The most parsimonious combination of RNA that can accurately differentiate DLB from AD will be identified using a novel AI-algorithm. A prototypic clinically adaptable multiplex RNA assay will be designed using the combination.
University of Leicester