Project Details

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Professor Robert Dineen

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Project area or title

Advanced brain imaging to understand mechanisms of disease modifying drug-withdrawal symptoms in people with multiple sclerosis


Around 30-60% of people with multiple sclerosis (MS) treated with disease-modifying monoclonal antibodies therapies experience wearing-off symptoms (WoS) including fatigue (>90%), cognitive difficulties, headache, low mood, pain and flu-like symptoms. The mechanisms of WoS are not understood but may have an immunological basis that overlaps with other conditions associated with similar symptoms where an inflammatory cascade results in brain state changes. In this project the student will use advanced MRI to study brain network changes related to WoS development, and to identify brain imaging features and neurocognitive profiles that are associated with increased risk for development of WoS.


Physical Health and Mental Health Multimorbidity


University of Nottingham