Project Details

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Professor Elizabeta Mukaetova-Ladinska

Project area or title

Clinical and peripheral biochemical biomarkers for diagnosing young onset dementia


Many younger people presenting with memory complaints would have functional cognitive impairment (FCI). This is defined as complaints about memory function or another cognitive process in the absence of relevant neuropathology and with evidence of inconsistency between symptoms reported and signs identified at assessment. FCI is most frequently associated with depression and anxiety, with suggestions of a linear association of severity of depression and FCI. Further to this, research focusing on neuroscience models and physiological changes on cognitive decline in depression shows changes in orbitofrontal cortex and hippocampus in people with depression.

This project will address clinical and peripheral (blood, and CSF biomarkers) that can differentiate FCI from dementia in younger people. The results from this research project have a potential to be directly applicable for use in clinical setting , both in primary and secondary care.




University of Leicester