Project area or title
GAD antibodies and neuropsychological associations
Autoimmunity to glutamate decarboxylase (GAD) contributes to neurological conditions including limbic encephalitis, stiff person syndrome and cerebellar ataxia. Recent studies in our laboratory identified T cell epitopes from GAD that promote autoantibodies. Here we will screen patients with these and other neurological conditions for levels of anti-GAD antibodies in blood and CSF. We will correlate these with levels of peripheral blood anti-GAD T cell responses. Identification of dominant T cell epitopes from GAD allows us to design antigen-processing independent T cell epitopes that can switch off antigen-specific T cells in vivo and hence block the autoimmune response to this protein.
Physical Health and Mental Health Multimorbidity
University of Birmingham