Project area or title
Studying cerebral control of gait in Mild Cognitive Impairment (MCI)
Gait abnormalities is a predictor of developing dementia and dual task gait help detect Mild cognitive impairment (MCI) patients with high risk to develop dementia. Some patients with Alzheimer’s disease (AD) present with early gait difficulties. Currently, patients with MCI need to have invasive lumbar puncture, seeking traces of neurodegeneration and/or radioactive positron emission tomography imaging, to identify whether they are likely to develop AD. Using OPM-MEG, brain activation and connectivity can be studied while sitting, standing or walking. We would like to study brain activation changes in these conditions, as an early predictor of progressive neurodegeneration at our deeply phenotyped group of patients with MCI.
University of Nottingham